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The development of the smallpox vaccine is attributed to Edward Jenner, who is often regarded as the father of immunology. In 1796, Jenner conducted an experiment where he inoculated a young boy with material taken from a cowpox sore, which led to the boy becoming immune to smallpox. This groundbreaking work laid the foundation for the concept of vaccination, which involves introducing a harmless form of a pathogen to stimulate the immune system.

Jenner's pioneering work was instrumental in demonstrating that exposure to a related virus could confer protection against a more harmful one. This technique proved fundamental in limiting and eventually eradicating smallpox, making it one of the first diseases to be successfully controlled by a vaccine. The approaches developed by Jenner set the stage for later advances in immunology and vaccination efforts against other infectious diseases.

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